Telomere length and possible link to X chromosome
نویسندگان
چکیده
منابع مشابه
A Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2
BACKGROUND Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function independently to regulate telomere length and protect chromosome ends, respectively. RESULTS Here, we show that TRF1 and TRF2 are linked via TIN2, a previously identified TRF1-interacting protein, and its novel binding partner TINT1. TINT1 localized to telomeres via TIN2...
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Phthalates or phthalic acid esters are a class of synthetic chemicals used as plasticizers to soften polyvinyl chloride (PVC) in a wide range of consumer and personal care products. Phthalates are released into the environment and taken up by the general population mainly through ingestion, inhalation, and dermal contact. Phthalates are lipid soluble, have relatively short (less than 24 h) biol...
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BACKGROUND Telomere dysfunction is involved in the development of breast cancer and very short telomeres are frequent genetic alterations in breast tumors. However, the influence of telomere lengths of specific chromosomal arms on the breast cancer risk is unknown. METHODS We conducted a case-control study of breast cancer to examine the associations of the telomere length on chromosome 9 sho...
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Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trigger cellular responses to telomere dysfunction, we crossed mTR-/- G6 mice that have short telomeres with mice heterozygous for telomerase (mTR+/-) that have long telomeres. The phenotype of the telomerase null offspring was similar to that of the late generation parent, although only half...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2004
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(04)15535-9